Motor and non-motor features of Parkinson\'s disease
نویسندگان
چکیده
منابع مشابه
Striatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease
BACKGROUND The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS We conducted a prospective sur...
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Degeneration of several brainstem nuclei has been long related to motor and non-motor symptoms (NMSs) of Parkinson's disease (PD). Nevertheless, due to technical issues, there are only a few studies that correlate that association. Brainstem auditory-evoked potential (BAEP) and vestibular-evoked myogenic potential (VEMP) responses represent a valuable tool for brainstem assessment. Here, we inv...
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Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus pallidus internus, both of which uniformly i...
متن کاملGBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease
The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson's disease (PD). Mutations carriers have earlier disease onset and are more likely to develop neuropsychiatric symptoms than other sporadic PD cases. These symptoms have primarily been observed in Parkinson's patients carrying the most common pathogenic mutations L444P and N37...
متن کاملNon-Motor and Motor Features in LRRK2 Transgenic Mice
BACKGROUND Non-motor symptoms are increasingly recognized as important features of Parkinson's disease (PD). LRRK2 mutations are common causes of familial and sporadic PD. Non-motor features have not been yet comprehensively evaluated in LRRK2 transgenic mouse models. OBJECTIVE Using a transgenic mouse model overexpressing the R1441G mutation of the human LRRK2 gene, we have investigated the ...
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ژورنال
عنوان ژورنال: East African Medical Journal
سال: 2008
ISSN: 0012-835X
DOI: 10.4314/eamj.v85i1.9599